alternatively spliced human tissue factor and thrombotic tendencies in hemodialysis patients
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منابع مشابه
Alternatively Spliced Tissue Factor Is Not Sufficient for Embryonic Development
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encoding membrane-anchored full-length TF (flTF) and soluble alternatively-spliced TF (asTF). The complete knockout of TF in mice causes embryonic lethality associated with failure of the yolk sac vasculature. Although asTF plays roles in postnatal angiogenesis, it is unknown whether it activates coag...
متن کاملTissue-specific distributions of alternatively spliced human PECAM-1 isoforms.
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell adhesion molecule that is highly expressed on the surface of endothelial cells and some hematopoietic cells. Its cytoplasmic domain is encoded by multiple exons, which undergo alternative splicing. Here, we demonstrate that the human PECAM-1 cytoplasmic domain undergoes alternative splicing, generating six different isoforms. RT-...
متن کاملAn alternatively spliced variant of KLK4 expressed in prostatic tissue.
P cancer is the third leading cause of malignancy-related deaths in North America. Despite the availability of such good markers as the two members of the kallikrein family, prostate specific antigen (PSA), and human glandular kallikrein 2 (hK2), the necessity to find additional markers still remains to differentiate aggressive from nonaggressive forms of this cancer. In the quest of further ch...
متن کاملNonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models.
This study was performed to determine whether murine alternatively spliced tissue factor (masTF) acts analogously to human alternatively spliced tissue factor (hasTF) in promoting neovascularization via integrin ligation. Immunohistochemical evaluation of a spontaneous murine pancreatic ductal adenocarcinoma model revealed increased levels of masTF and murine full-length tissue factor (mflTF) i...
متن کاملAlternatively Spliced Genes
2 Alternative pre-mRNA Splicing 17 2.1 Alternative Splicing and its Role in Regulating Gene Activities and Generating Genetic Diversity 17 2.1.1 Different Patterns of Alternative Splicing 17 2.1.2 Alternative Splicing and Genetic Diversity 18 2.2 Mechanisms Underlying Alternative Splicing Regulation 19 2.2.1 Splicing Signals and Splicing Regulatory Elements 20 2.2.2 Trans-acting Splicing Regula...
متن کاملHuman complement factor H: two factor H proteins are derived from alternatively spliced transcripts.
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that a least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are constitutively expressed in human liver. In addition, several factor H-related proteins have been detected in human sera using antibodies directed agains...
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عنوان ژورنال:
nephro-urology monthlyجلد ۲۰۱۶، شماره ۱۱، صفحات ۱۹۳-۱۹۹
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